THE ROLE OF PROBABILISTIC INFORMATION ON AFFECTIVE PREDICTIONS: NEURAL AND SUBJECTIVE CORRELATES AS MODULATED BY INTOLERANCE OF UNCERTAINTY

Emotions have been recently reconsidered as interoceptive predictive models, “constructed” by the brain on the basis of contextual information and prior experience, with the aim to predict relevant stimuli or events, and to provide the organism with optimal resources for survival. Nevertheless, the specific mechanisms underlying the construction of affective predictions both at the neural and subjective experience level remain unclear. More specifically, both the role played by contextual information and prior experience on the one hand, and the potential interactions with dispositional characteristics such as Intolerance of Uncertainty (IU), which is considered a trans-diagnostic risk factor for affective disorders, on the other hand, have yet to be unraveled. The present thesis aimed to answer these open questions. As a first aim, we investigated how contextual information of different predictive value modulates the neural correlates of affective predictions construction. Second, we explored how prior probabilistic experience affects the construction of affective predictions at the subjective experience level. Third and last, we studied how individual differences in IU impact on the construction of affective predictions as a function of contextual information and prior experience. Taken together, this thesis contributes to untangling the dynamics of affective prediction construction at the neural and subjective experience level. Contextual information and prior experience were found to differently influence (depending on their predictive value), and to interact with IU, in shaping the neural correlates and the subjective experience of emotion along the construction of affective predictions. Thus, this work offers both a theoretical contribution to predictive models of emotion, by better clarifying the mechanisms subtending prediction construction at the neural and subjective experience levels, and potential clinical implications for the prevention and treatment of anxiety disorders, given the trans-diagnostic nature of IU as a risk factor for the development of affective psychopathology.Emotions have been recently reconsidered as interoceptive predictive models, “constructed” by the brain on the basis of contextual information and prior experience, with the aim to predict relevant stimuli or events, and to provide the organism with optimal resources for survival. Nevertheless, the specific mechanisms underlying the construction of affective predictions both at the neural and subjective experience level remain unclear. More specifically, both the role played by contextual information and prior experience on the one hand, and the potential interactions with dispositional characteristics such as Intolerance of Uncertainty (IU), which is considered a trans-diagnostic risk factor for affective disorders, on the other hand, have yet to be unraveled. The present thesis aimed to answer these open questions. As a first aim, we investigated how contextual information of different predictive value modulates the neural correlates of affective predictions construction. Second, we explored how prior probabilistic experience affects the construction of affective predictions at the subjective experience level. Third and last, we studied how individual differences in IU impact on the construction of affective predictions as a function of contextual information and prior experience. Taken together, this thesis contributes to untangling the dynamics of affective prediction construction at the neural and subjective experience level. Contextual information and prior experience were found to differently influence (depending on their predictive value), and to interact with IU, in shaping the neural correlates and the subjective experience of emotion along the construction of affective predictions. Thus, this work offers both a theoretical contribution to predictive models of emotion, by better clarifying the mechanisms subtending prediction construction at the neural and subjective experience levels, and potential clinical implications for the prevention and treatment of anxiety disorders, given the trans-diagnostic nature of IU as a risk factor for the development of affective psychopathology

Doing Experimental Psychological Research from Remote: How Alerting Differently Impacts Online vs. Lab Setting

Due to pandemic-imposed restrictions on lab-based research, we have recently witnessed a flourishing of online studies in experimental psychology, based on the collection of fine behavioral measures such as reaction times (RTs) and accuracy. However, it remains unclear whether participants’ alerting levels may have a different impact on behavioral performance in the online vs. lab setting. In this work we administered online and in-lab the dynamic temporal prediction (DTP) task, which requires an implicit modulation of participants’ alerting by alternating experimental conditions implying either slower or faster response rates. We then compared data distribution, RTs, accuracy, and time-on-task effects across the adult lifespan between the settings. We replicated online and across the whole age range considered (19–69 y) all the task-specific effects already found in-lab (both in terms of RTs and accuracy) beyond the overall RTs delay typical of the online setting. Moreover, we found an interaction between the setting and task-specific features so that participants showed slower RTs only in experimental conditions implying a less urgent response rate, while no RTs delay and a slight accuracy increase emerged in faster conditions. Thus, the online setting has been shown to be methodologically sound in eliciting comparable effects to those found in-lab. Moreover, behavioral performance seems to be more sensitive to task-induced alerting shifts in the online as compared to the lab setting, leading to either a heightened or reduced efficiency depending on a faster or slower response rate of experimental conditions, respectively

Does your past define you? The role of previous visual experience in subjective reactions to new affective pictures and sounds

According to predictive models of emotion, people use previous experience to construct affective predictions, represented multimodally in the brain. We do not live in a stable world, however. Some environments are uncertain, whereas others are not. In two experiments we investigated how experiencing previous certain versus uncertain contingencies shaped subjective reactions to future affective stimuli, within and across sensory modalities. Two S1-S2 paradigms were used as learning and test phases. S1s were colored circles, S2s negative/neutral affective pictures or sounds. During the learning phase, participants (N = 192, 179) were assigned to the certain (CG) or uncertain group (UG) and presented with 100% (CG) or 50% (UG) S1-S2 congruency between visual stimuli. During the test phase, participants were presented with a new 75% S1-S2 paradigm and visual (Experiment 1) or auditory (Experiment 2) S2s. Participants were asked to rate the expected valence of upcoming S2s (expectancy ratings) or valence and arousal to S2s. In both experiments, the CG reported more extreme expectancy ratings than the UG, suggesting that experiencing previous reliable S1-S2 associations led CG participants to subsequently predict similar associations. No group differences emerged on valence and arousal ratings, which were more prominently influenced by the new 75% contingencies of the test phase rather than by previous learned contingencies. Last, comparing the two experiments, no significant group by experiment interaction was found, supporting the hypothesis of cross-modality generalization at the subjective level. Overall, our results advance knowledge about the mechanisms by which previous learned contingencies shape subjective affective experience